For grading, The universities just your best 6 subjects ( 3 core subjects and 3 electives.)
The core subjects are
Social Studies or Integrated Science.
If the course you want to pursue is science related, it is natural that you do well in science because you will stand a better chance of getting admission. On the other hand, if you are going to pursue business, you can substitute social for science or science for social depending on which one you did well. In legon and ucc, business students offering business courses will doing a science related course for just one semester. So for business student, your job is to get good grades in either social or science or better still both.